Alexis de Tocqueville asserted that America had no truly great literature, and that American writers merely mimicked the British and European traditions of the eighteenth and nineteenth centuries. This new edited collection masterfully refutes Tocqueville's monocultural myopia and reveals the distinctive role American poetry and prose have played in reflecting and passing judgment upon the core values of American democracy. The essays, profiling the work of Mark Twain, F. Scott Fitzgerald, John Updike, Edith Wharton, Walt Whitman, Henry James, Willa Cather, (...) Walker Percy, and Tom Wolfe, reveal how America's greatest writers have acted as society's most ardent cheerleaders and its most penetrating critics. Christine Dunn Henderson's exciting new work offers literature as a portal through which to view the philosophical principles that animate America's political order and the mores which either reinforce or undermine them. (shrink)

The search for an ethics rooted in human experience is the crux of this deeply compassionate work, here translated from the 1983 German edition. Distinguished philosopher Werner Marx provides a close reading, critique, and _Weiterdenken_, or "further thinking," of Martin Heidegger's later work on death, language, and poetry, which has often been dismissed as both obscure and obscurantist. In it Marx seeks, and perhaps finds, both a measure for distinguishing between good and evil and a motive for preferring the former. (...) The poet Hölderlin posed the question, "Is there a measure on earth?" His own answer was emphatic, "There is none," for he was convinced that the measure for man was to be found only in the domain of the heavenly beings. Such metaphysical assumptions, as well as the attempt to found ethical conduct in the nature of man as a rational being, have been rejected by many contemporary thinkers, particularly Heidegger. Yet these thinkers have not been able to provide a satisfactory alternative to metaphysical foundations of the standards for responsible human conduct. Marx, therefore, goes beyond Heidegger in demonstrating how several of his most basic notions could be relevant to a secular morality in our age. It is death, Marx claims, that unsettles man and transforms his conduct toward his fellow man. the common experience of mortality nourishes ethical life—and leads to the measures of compassion, love, and recognition of one's fellow human beings. "It is only on the basis of these 'traditional virtues,'" Marx writes, "that we can find a motive for averting the impending dangers which have often enough been described so vividly and convincingly.". (shrink)

Book reviewed in this article: The Code of Codes: Scientific and Social Issues in the Human Genome Project. Edited by Daniel J. Kevles and LeRoy Hood. Wonderwoman and Superman: The Ethics of Human Biotechnology. By John Harris.

Religion is intrinsically social, and hence irretrievably organizational, although organization is often seen as the darker side of the religious experience--power, routinization, and bureaucracy. Religion and secular organizations have long received separate scholarly scrutiny, but until now their confluence has been little considered. This interdisciplinary collection of mostly unpublished papers is the first volume to remedy the deficit. The project grew out of a three-year inquiry into religious institutions undertaken by Yale University's Program on Non-Profit Organizations and sponsored by the (...) Lilly Endowment. The scholars who took part in this effort weree challenged to apply new perspectives to the study of religious organizations, especially that strand of contemporary secular organizational theory known as "New Institutionalism." The result was this groundbreaking volume, which includes papers on various aspects of such topics as the historical sources and patterns of U.S. religious organizations, contemporary patterns of denominational authority, the congregation as an organization, and the interface between religious and secular institutions and movements. The contributors include an interdisciplinary mix of scholars from economics, history, law, social administration, and sociology. (shrink)

Fertilization is the result of a series of successful recognition and binding events mediated by gamete surface molecules. Recent advances in the identification and characterization of some of these recognition molecules provide extremely valuable information necessary to understand sperm‐egg recognition and subsequent egg activation. We discuss these new data in the context of the model of gamete recognition first proposed by F.R. Lillie in the early part of the 20th century, and revisited periodically in the subsequent literature, which relates fortilization (...) events to those of immune cell recognition and activation events. Here we discuss the principles underlying the molecular recognition and activation mechanisms of gametes and immune cells. (shrink)

The last two words of the title for this essay are taken from a paper by R. S. Lillie, and the first phrase is also taken by implication from the same source. The study of chemical phenomena in life has progressed far enough so that underlying chemical causes, involved in Professor Lillie's picture of Biological Causation, may in part be discussed in general terms, and apart from the mass of detail known about the agents and processes involved. Moreover, this mass (...) of detail is now great enough so that even though we are far from having a complete or even a comprehensive picture of these causes at least some of the fundamental principles involved in the chemical aspects of biological causation are clearly revealed. (shrink)

This essay is concerned with concentrations of entities, which play an important—albeit often overlooked—role in scientific explanation. First, I discuss an example from molecular biology to show that concentrations can play an irreducible causal role. Second, I provide a preliminary philosophical analysis of this causal role, suggesting some implications for extant theories of causation. I conclude by introducing the concept of causation by concentration, a form of statistical causation whose widespread presence throughout the sciences has been unduly neglected and which (...) deserves to be studied in more depth. 1 Introduction2 Solving Lillie's Paradox: Lysogenic Induction in Phage λ3 Repressor Concentration and the Tuning of the Switch4 Concentration and Causality5 Preemption in Concentrations: Analysis and Implications6 Causation by Concentration: General Definition, Refinements, and Further Applications. (shrink)

Alzheimer's disease is characterized by formation of neuritic plaque primarily composed of a small filamentous protein called amyloid-beta peptide . The rate-limiting step in the production of Abeta is the processing of Abeta precursor protein by beta-site APP-cleaving enzyme . Hence, BACE1 activity plausibly plays a rate-limiting role in the generation of potentially toxic Abeta within brain and the development of AD, thereby making it an interesting drug target. A phase II trial of the promising LY2886721 inhibitor of BACE1 was (...) suspended in June 2013 by Eli Lilly and Co., due to possible liver toxicity. This outcome was apparently a surprise to the study's team, particularly since BACE1 knockout mice and mice treated with the drug did not show such liver toxicity. Lilly proposed that the problem was not due to LY2886721 anti-BACE1 activity. We offer an alternative hypothesis, whereby anti-BACE1 activity may induce apparent hepatotoxicity through inhibiting BACE1's processing of beta-galactoside alpha-2,6-sialyltransferase I . In knockout mice, paralogues, such as BACE2 or cathepsin D, could partially compensate. Furthermore, the short duration of animal studies and short lifespan of study animals could mask effects that would require several decades to accumulate in humans. Inhibition of hepatic BACE1 activity in middle-aged humans would produce effects not detectable in mice. We present a testable model to explain the off-target effects of LY2886721 and highlight more broadly that so-called off-target drug effects might actually represent off-site effects that are not necessarily off-target. Consideration of this concept in forthcoming drug design, screening, and testing programs may prevent such failures in the future. (shrink)

Contributing Authors: Lilli Alanen & Frans Svensson, David Alm, Gustaf Arrhenius, Gunnar Björnsson, Luc Bovens, Richard Bradley, Geoffrey Brennan & Nicholas Southwood, John Broome, Linus Broström & Mats Johansson, Johan Brännmark, Krister Bykvist, John Cantwell, Erik Carlson, David Copp, Roger Crisp, Sven Danielsson, Dan Egonsson, Fred Feldman, Roger Fjellström, Marc Fleurbaey, Margaret Gilbert, Olav Gjelsvik, Kathrin Glüer & Peter Pagin, Ebba Gullberg & Sten Lindström, Peter Gärdenfors, Sven Ove Hansson, Jana Holsanova, Nils Holtug, Victoria Höög, Magnus Jiborn, Karsten Klint Jensen, (...) Sigurður Kristinsson, Isaac Levi, Kasper Lippert-Rasmussen, David Makinson, Anna-Sofia Maurin, Philippe Mongin, Kevin Mulligan, Lennart Nordenfelt, Jonas Olson, Erik J. Olsson, Ingmar Persson, Johannes Persson, Björn Petersson, Philip Pettit, Hans Rott, Toni Rønnow-Rasmussen, Krister Segerberg, John Skorupski, Howard Sobel, Fredrik Stjernberg, Fred Stoutland, Caj Strandberg, Pär Sundström, Folke Tersman, Torbjörn Tännsjö, Peter Vallentyne, Bruno Verbeek, Stella Villarmea, and Michael J. Zimmerman. (shrink)

Interest in John Maynard Keynes has increased significantly over the past decade with the publication of his collected writings, increased access to his unpublished papers, and the resulting explosion of secondary literature. Responding to this renewed attention, this collection brings together economists and historians of economics with scholars from philosophy and other related fields to reconsider Keynes’s work and its legacy. Several of these essays look at Keynes not simply as an economist, but more broadly as a philosopher. Special attention (...) is directed to his views on aesthetics and moral philosophy, as well as his contributions as a probability theorist. The development of the Keynesian heritage is also considered: How did Keynesian ideas become assimilated and domesticated into the mainstream of economic thought—to the point of becoming dominant as the orthodoxy of the economics profession? What was the relationship between postwar British conservatives, Keynes’s work, and Britain’s relative economic decline? The archivist in charge of Keynes’s papers provides an additional vantage point on Keynes’s working methods and the broad range of scholars interested in his writings. Finally, all of the essays are followed by a responder’s comments, thus providing an exchange of viewpoints. _Contributors. _A. W. Coats, Allin F. Cottrell, Jacqueline Cox, William Darity, John Davis, Robert Dimand, Peter Groenewegen, Kevin Hoover, Henry E. Kyburg Jr., David Laidler, Michael S. Lawlor, Greg Lilly, D. E. Moggridge, R. M. O’Donnell, Kerry Pearce, Jochen Runde, Teddy Seidenfeld, J. D. Tomlinson. (shrink)

Can original philosophy be done while simultaneously engaging in the history of philosophy? Such a possibility is questioned by analytic philosophers who contend that history contaminates good philosophy, and by historians of philosophy who insist that theoretical predecessors cannot be ignored. Believing that both camps are misguided, the contributors to this book present a case for historical philosophy as a valuable enterprise. The contributors include: Todd L. Adams, Lilli Alanen, Jos? Bernardete, Jonathan Bennett, John I. Biro, Phillip Cummins, Georges Dicker, (...) Daniel A. Dombrowski, Daniel Garber, Josiah Gould, Jorge J.E. Gracie, Daniel Graham, Charles Griswold, James Lawler, Rudolf Luthe, Edward H. Madden, George Mavrodes, Gerald E. Myers, Jonathan R?e, Frithjof Rodi, Kenneth L. Schmitz, Vladimir Shtinov, David G. Stern, Robert Turnbull, James Van Cleve, Frederick Van De Pitte, Henry Beatch, and Richard Watson. (shrink)

The definition of acedia presents unique conceptual problems among the eight Evagrian logismoi. Its descriptions are so complex and varied as to render the concept seemingly incoherent. This article argues that the conceptual unity of acedia has been obscured by the translation of Evagrian logismoi into the ‘deadly sins’ tradition, resulting in a category error. Acedia is more properly understood, not as a psychological state or a sin, but rather as an array of demonic temptations with the unifying end-goal of (...) interrupting the anchoritic ideal of sustained contemplation. (shrink)

Four essays of interest to the philosopher of science. The collection includes three short essays by L. P. Coonen, D. M. Lilly and C. DeKoninck. In the major essay, "Evolution: Scientific and Philosophical Dimensions," R. J. Nogar first presents a detailed analysis of the current status of the concept of evolution, showing that its meaning varies greatly from discipline to discipline. He argues that in view of the great stability of organic species, the consideration of evolutionary processes exclusively as (...) space-time distributions in inadequate, and needs supplementing by a concept of "nature," to explicate the relation between generator and generated, and the facts of heredity.--K. P. F. (shrink)

Part intellectual autobiography and part exposition of complex yet contemporary economic ideas, this lively conversation with renowned scholar and public intellectual Kenneth J. Arrow focuses on economics and politics in light of history, current events, and philosophy as well. Reminding readers that economics is about redistribution and thus about how we treat each other, Arrow shows that the intersection of economics and ethics is of concern not just to economists but for the public more broadly. With a foreword by Amartya (...) Sen, this book highlights the belief that government can be a powerful force for good, and is particularly relevant in the current political climate and to the lay reader as well as the economist. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 539 ls There a Measure on Earth? Foundations for a Nonmetaphysical Ethics. By WERNER MARX. Trans. Thomas J. Nenon and Reginald Lilly. Chicago: University of Chicago Press, 1987. Pp. 172. (Hardcover.) (Originally published as Gibt es au/ Erden ein Mass? Grundbestimmungen einer nichtmetaphysischen Ethik. Hamburg: Felix Meiner, 1983.) Is there a non-metaphysical earthly measure for responsible action? Marx takes his question from Holderlin and directs it (...) at Heidegger, in whom Marx finds no explicit answer. It is not the case that Heidegger simply fails to ask or answer this question, but rather that the corpus of Heidegger's later work itself motivates the question and leaves us searching for the path to an answer which must, on Heideggerian principles, differ from the one embraced by Holderlin, Schelling, and the metaphysical tradition in general. Marx explores.the various possibilities offered in Heidegger's texts but fails to. find a definite answer with respect to a measure for responsible action. In his concise interpretation Marx is led in one inevitable direction--4:owards the concept of death. How does death qualify as a measure for action? Before he addresses this question Marx attempts to understand 1the concept of measure, which, he contends, can be viewed as either a metaphysical or a nonmetaphysical concept. He sets out the metaphysical concept of measure on the basis of his reading of Schelling. Schelling's onto-theological concept of measure is characterized as normative, transcendent, immanently powerful, obligatory, self-same, manifest and univocal (20). This conception is then taken to represent the traditional metaphysical position. Here a number of questions could be raised regarding what Marx himself calls the "not completely satisfactory route" of his own analysis (17). One could certainly agree with his beginning assumption, "ithat our contemporary understanding of measure still contains certain residual traditional meanings" (17). But the stronger and genuinely operative assumption in Marx's analysis is more questionable. Why does Schelling's conception stand as.the representative of an entire metaphysical tradition? Although Schelling's conception of measure nicely facilitates Marx's projecl: vis-a-vis Heidegger, the reader might remain unconvinced that the full metaphysical conception of measure is reflected therein. Consider, for example, Marx's contention ithat 1the traditional measure is univocal and therefore leaves no room for ambiguity (42). On this basis he asserts that we cannot take Heidegger's notion of "the fourfold," which involves an "inner mobility " of play, as a.traditional measure. The ambiguity and "basic 540 BOOK REVIEWS instability inherent in playing and mirroring is irreconcilable with the traditional meaning of a measure" (42). By avoiding the more extensive analysis to which he makes reference, Marx neatly steps around an extremely important problematic involved in the concepts of ambi· guity and univocity. The following question indicates this problem in the simplest way: Does univocity belong to the measure itself or to our perception or predication of the measure? We might say, for example,,that there is no ambiguity in God, but that there is a high degree of ambiguity involved in our perception or predication of God. Certainly in the tradition, whether we take Arisotle's spoudaios, or God's eternal law, or Christian love in the model of Christ as our measure, we do not escape the ambiguity of our own finite interpretations. Thus Aristotle's caution about.the nature of ethics (N. Ethics 1094bl2-15), Aquinas's qualification about knowing the natural law with respect to details (ST 94,, 4), or Kierkegaard's acknowledgment of the paradox of Christ. This problematic is also to be found in Heidegger's writings where he indicates a play of concealedness-unconcealedness involved in Being or "the fourfold," and thus an ambiguity in the measure itself. But would Heidegger say that this concealing-unconcealing play of Being is something that happens in itself, outside of language, or independent· ly of the one who is looking after Being? (See Marx's discussion, 9192, 123). The difference between Heidegger and the tradition on this point is.this: in the tradition the " location " of ambiguity is unambiguous ; it is found in human perception, language, and reason, hut not in the measure itself. In Heidegger, ·the location... (shrink)

It would be a mistake to attempt to identify in modern terms the disease of Galerius described so graphically by Lactantius, Mort. 33. Consumption by lice or worms, if not genital ‘gangrene’, was a typical end for a tyrant or the impious, and there must be an element of literary exaggeration in Lactantius' account. But whatever one makes of the nature of the illness, Lactantius did set out to give the passage a scientific plausibility by his use of technical medical (...) phraseology, and by an allusion to a medical theory at 33.7. Recognition of this theory allows one to settle the text at one point, where editors have failed to agree. There is also a second place in the chapter where familiarity with medical Latin points one towards the solution of a textual problem. (shrink)

The demonstration by E. Wölfflin that between theHistoriesandAnnalsTacitus progressed towards a more archaic and artificial style is well known. From the outset Tacitus adhered to the traditional Roman view that history should be composed in an archaic language remote from everyday usage ; but he was apparently at first not fully aware of the possibilities of the archaizing style. New archaisms and artificial usages suggested themselves as he advanced ; and others, which he had used sporadically even early in theHistories, (...) were allowed to oust ordinary alternatives completely. (shrink)

Takeuti introduced an infinitary proof system for determinate logic and showed that for transitive models of Zermelo-Fraenkel set theory with the Axiom of Dependent Choice that contain all reals, the cut-elimination theorem is equivalent to the Axiom of Determinacy, and in particular contradicts the Axiom of Choice. We consider variants of Takeuti's theorem without assuming the failure of the Axiom of Choice. For instance, we show that if one removes atomic formulae of infinite arity from the language of Takeuti's proof (...) system, then cut elimination is equivalent to a determinacy hypothesis provable, e.g., in ZFC + “there are infinitely many Woodin cardinals.” A slight extension of the proof system admits cut elimination for countable sequents under the same assumptions. A simple modification of the proof system yields analogs of the results above for the Axiom of Real Determinacy and uncountably many Woodin cardinals. (shrink)

This essay answers the question: Which are the themes often considered as “Philosophy of Law” that are of concern to legal scholars? My answer seeks to sort out how the “thematic content” has become into what today is known as “Philosophy of Law” to legal scholars (against “Philosophy of Law” to philosophers). To deal with this question I will consider Norberto Bobbio’s point of view.Resumen:En este texto trato de responder a la pregunta: ¿cuáles son los temas calificados generalmente como “de (...) filosofía del derecho” que nos interesan a los juristas? Mi respuesta se dirige a desgranar cómo se ha ido construyendo el “contenido temático” más habitual que hoy identifica a la filosofía del derecho de los juristas (frente a la filosofía del derecho de los filósofos). Para tratar esta cuestión examino el punto de vista de Norberto Bobbio. En nuestro tiempo, dicha perspectiva constituye el punto de partida en la discusión de cuáles son los ámbitos problemáticos más habituales de la reflexión teórico-jurídica. (shrink)

This essay subjects to criticism the historical and philosophical attitudes to political thought found in the writings of John Dunn and Michael Oakeshott. The essay does not limit itself to criticism but attempts to elaborate what is indicated by criticism for the sake of the modern understanding of political thought. The argument is that history and philosophy as they have recently been practised suffer from limitations that can only be addressed by a recognition of something which is here called theology. (...) The significance of such a recognition is considered with regard to the history of political thought, political philosophy and finally to theology itself. The emphasis on theology makes it necessary to say that the essay is written for the benefit of historians and philosophers, not theologians. Although it is an argument for theology it is in no sense an argument from theology. Whether this is a contradictory position may require consideration elsewhere; but since the essay is a first step rather than a final step in an argument, it may gain more than it loses by such a contradiction, if there is one. (shrink)

J. David Archibald explores how Darwin first came to the conclusion that species had evolved in different regions throughout the world. Carefully retracing Darwin's gathering of evidence and the evolution of his thinking, Origins of Darwin's Evolution achieves a new understanding of how Darwin crafted his transformative theory.